The Science Behind Artificial Sweeteners | Are They Safe? Are They Making Us Fat?

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    Time Stamps:
    ▹Acceptable Daily Intake Explanation‣ 2:07
    ▹Aspartame ‣ 3:07
    ▹Sucralose ‣ 6:33
    ▹Acesulfame Potassium ‣ 7:54
    ▹Saccharin ‣ 10:08
    ▹Stevia ‣ 10:55
    ▹Weight Gain/Increased Appetite ‣ 12:47

    •National Cancer Institute- Artificial Sweeteners and Cancer
    •American Cancer Society - Aspartame
    •Magnuson et al., 2016 - Biological fate of low-calorie sweeteners
    •Mallikarjun & Sieburth, 2015 - Aspartame and Risk of Cancer: A Meta-analytic Review
    •Sharma et al., 2016 - Artificial sweeteners as a sugar substitute: Are they really safe?
    •Ma et al., 2009 - Effect of the artificial sweetener, sucralose, on gastric emptying and incretin hormone release in healthy subjects
    •Bian et al., 2017 - The artificial sweetener acesulfame potassium affects the gut microbiome and body weight gain in CD-1 mice
    •Urban et al., 2013 - Steviol glycoside safety: Is the genotoxicity database sufficient?
    •Tate et al., 2012 - Replacing caloric beverages with water or diet beverages for weight loss in adults
    •Anton et al., 2010 - Effects of stevia, aspartame, and sucrose on food intake, satiety, and postprandial glucose and insulin levels
    •Fitch & Keim, 2012 - Position of the Academy of Nutrition and Dietetics: Use of Nutritive and Nonnutritive Sweeteners
    •Schiffman et al., 1987 - Aspartame and Susceptibility to Headache
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    AYOOO!! My name is Stephanie Buttermore and in a few words I am a fitness enthusiast but a scientist at heart!
    Just obtained my Ph.D. in pathology and cell biology with a research focus on the molecular mechanisms that drive ovarian cancer progression. Hope you stick around! xoxo

    Közzététel: 3 évvel


    1. Stephanie Buttermore

      Happy 2018! Hope you enjoy this video! I spent a long time preparing it so I would really appreciate it if you let me know if you like this type of long form content from me 🙏 Or if you’d rather short “to the point” videos. Much love xoxo ❤️

      1. MrLickenz


      2. fire trails

        since most sweeteners don't just contain the extracts do those sweeteners that contain other chemicals have calories?

      3. Olga Lucia Luna Barrera

        Stephanie, what about art sweeteners during pregnancy? Any supplements during pregnancy actually!! Thank you 😊

      4. Maiguel Moreno

        This is just superb, been searching for "gym routine for bulking up" for a while now, and I think this has helped. Have you heard people talk about - Senictoria Bulking Paradise - (just google it ) ? Ive heard some great things about it and my m8 got cool success with it.

      5. Richard Breeze

        Ah there is a study i think you overlooked about sucralose destroying the microbiome by 50% and other negative effects. Journal of Toxicology and Environmental Health. Part B, Critical Reviews Taylor & Francis J Toxicol Environ Health B Crit Rev. 2013 Sep; 16(7): 399-451. Published online 2013 Nov 12. doi: 10.1080/10937404.2013.842523 PMCID: PMC3856475 PMID: 24219506 Sucralose, A Synthetic Organochlorine Sweetener: Overview of Biological Issues Aspartame: The Most Dangerous Substance on the Market. (n.d.). Retrieved from

    2. FiEnD749

      It's very essential and obvious why extreme dosages are used for determining potential adverse health effects in animal studies.

    3. Ida Kwiatkowska

      Please do this topic again 🙂 maybe there is something new in this area?

    4. Valerie Hearn

      I love this I still refer ppl to this when I hear questions or claims. Could you do a 2021 updated version of this

    5. Tiffany McRee

      I’ve watched this one 3x now.

    6. safrizal Bin Abdurrahman

      nice, thank you

    7. Santiago Bravo

      coming from 2021, great video. definitely needed this information for my health decisions.

    8. Vegeta

      20 studies done on saccharin. 19 studies found no adverse effects, 1 study found instances of bladder cancer (in rats that were already predisposed to bladder cancer). This study is the one everyone references when talking about saccharin because all the others yielded nothing of consequence. Saccharin is now banned in numerous countries. "Doubt is our product" ~ Brown & William Tabacco, 1969.

    9. Dina Salehi

      Wow, thank you so much for this very detailed explanation... so much respect for you!!! Thank you

    10. Get Probed

      this woman is a goddess

    11. SOCIanxiet Y

      Can someone please recommend me a artificial sweetener which is used or highly acceptable.

      1. SOCIanxiet Y

        @Scott Chasse thankyou

      2. Scott Chasse


    12. Bhaskar Purohit

      I just ordered 10 cans of diet soda after watching this.

    13. Boobles14045

      Ok but have you watched Ronda Patrick talk about it on JRE? She mentions, surprise, that there are harmful effects on your microbiome

    14. Boobles14045

      I love u and Jeff cause you guys tell me I can drink coke zero and do leg extensions/ glute abduction

    15. ᆰORØZCO

      Thx for clearing up the confusion. Facts vs Fiction.

    16. Celia Cavalli

      You rock! So much fear around this topic... For some reason stevia has such a great rap yet it’s the least studied 😟

    17. Clovis Shropshire

      Here from Jeff but had to sub for the awesome and very informative video. Keep up the great work!

    18. AZone TV

      C'est le pire les édulcorants .. il suffit par exemple de manger tout les jours une boîte de chewing gum ou de bonbons suisses que vous connaissez bien et il est partout l'aspartame vous vous rendez pas compte vous en mangez depuis vous etes tout petits , il y en a meme dans les yaourts ou dans les conserves . Il a infecté touts les plats préparés ,les boissons dont certaines sont vraiment du pétrole notamment le coca light ou zero censé vous etre benefique , healfy mais vous n'allez pas avaller ca quand meme ca fait des années et des années qu'on sait que ces merdes "sucrées" provoque cancer , Parkinson , Azeihmer , Hyperactivité , Obésité, AVC ,j'en passe beaucoup , et memes graves malformations du a la consommation de bonbons , boisson light , plats préparés etc... tout les jours, durant la grossesse Et LE PIRE c'est que ca te rends bien évidemment accro ! Tu te rends meme pas compte ! Mais heureusement a tout fleau qui existe , il y a toujours des solutions ! Si je peux vous evitez tout ca , S'IL VOUS PLAIT LISEZ LES ETIQUETTE , PRENEZ UNE LOUPE OU MEME INSTALLEZ L'APPLICATION YUKA POUR AVOIR LA QUALITÉ REELLE DU PRODUIT voila mon conseil final : NE FAITES PAS CONFIANCE AVEUGLEMENT AUX ETIQUETTES ET A TOUT LES MANIPULATEURS A LA TELE AU 20H CA POURRAIT VOUS SAUVER LA VIE ! je m'excuse pour tant de pessimisme mais malheureusement il faut bien gueuler pour qu'on reveille et qu'on revele nos erreurs . tenez un lien pour confirmer que ce que je dis c'est pas des conneries, tien d'ailleurs, la gentille dame dans la videos a disparue "mystérieusement" preuve qu'il y a quelque chose a cacher . Sinon je vous remercie d'avoir pris du temps si precieux pour lire mon commentaire ❤

    19. Nicole Watterson

      I hate Diet Coke. All I taste is chemicals. I drink regular Coke sometimes but I’m trying to drink more water.

    20. Dee'on Bellamy

      Just found this in 2020!!! Loved it! definitely will subscribe and can’t wait to see your other content

    21. Krunchy

      What about erythritol?

    22. jod enderson

      Loved this video

    23. jod enderson

      Sacred to watch this. Recovery from anorexia but love artificial sweeteners a lot. Helped me to actually no weight gain and I use hundreds of-no exactartions- packs a day for over 25 years and I am now 47

    24. obfuscatid

      Another study that focused on the metabolic effects of sucralose on environmental bacteria showed that sucralose can inhibit the growth of certain bacterial species (Omran et al., 2013). Therefore, sucralose may inhibit intestinal bacteria and alter the gut microbiota, and these alterations could affect host health. [Jul 24, 2017,]

    25. Vitanny

      You should definitely make more science-based videos!

    26. Vitanny

      What about Monkfruit sweetener?

    27. Zero1

      You're better off just having a little bit of sugar a little chocolate is good for the soul, a lot of chocolate is bad for the ass

    28. 111 23

      3:25 "two million people" What? Do you mean two billion people? Aspartame is everywhere. I think there are regular drinkers of Coke Zero way more than two million, not to mention countless other products that are sweetened with aspartame

    29. You’re cute c:

      The sun will kill you faster, enjoy a Coke Zero once in a while.

    30. paige sackett

      Great video! I really liked how you shared the evidence that backed all of this information. Thanks, this helps a bunch!

    31. Christina Serafin

      Hey Steph! Love your videos. I would be curious to know your take on artificial sweeteners and gut microbiome? There are many peer reviewed studies that speak towards this and I noted it wasn’t included in this video.

    32. SFGal9 2011

      Good grief, "The FDA said that it is safe for consumption up to #amount/day..." in itself is a scary and ridiculous proposition about "food."

    33. Beth Hatanaka

      This was very helpful and informative. Thank you!!

    34. Cecilia Rebeiro

      I’m very interested in hearing your studies and topics!! They’re always so informative and eye opening!

    35. Tori Mouradian

      This is now my favorite video on the internet! I'm so tired of being side eyed by others when I have a diet drink or zero calorie drink when I've done the research behind it, all the while they're consuming regular sugar by the handfuls. The hypocrisy, I swear! Anyway, lol, this video was so informative and thorough! Thank you Steph!!

    36. maggie boo

      Is stevia safe guys,?

    37. Schoening91

      The company that tried to sell Miracle Berries was basically lobbied out of existence by the sweetener companies in the US. So while we do have a lot of studies on the subject at this point I would still be a little cautious in overconsumption since we could have had a frigging berry sweetening our food, but instead, we got artificial sweeteners since they have the muscle to bully out a new product. So who knows how many studies are funded by said companies. Worth keeping in mind even if you consume artificial sweeteners.

    38. VirtualEthan _

      Such a high quality video.

    39. Elizabeth Schmidt

      super informative Stephanie thank you

    40. Viktor Borg Grelsson

      this video is great gj

    41. Salvador Hernandez

      i graduated and earned a phd :)?

    42. Nathan Fischer

      Thank you! I really appreciate your effort

    43. Brian Feeney

      This video is like a breath of fresh air in the fitness side of HUfast

    44. Alyssa Shoemaker

      Stevia has always been my go-to for sweetening coffee or healthy desserts 😊

    45. Vanessa Garibay

      Would you make an updated video about this? 🥰

    46. MrOmid1955

      great video thanks!

    47. Rekha Gupta

      Very informative

    48. Paul Grey

      Only 2 million people consume aspartame around the world regularly? This doesn't make sense.

    49. Matt F

      So if I want a diet coke once in a while then its ok.

    50. JUSTINE Kim

      I'm so glad that I found Stephanie's channel. I'm actually learning something from her videos. She makes complex topics so fun and easy to understand :)

    51. K. Roberts

      LOVE THIS! Please more. There is so much confusing nutrition content on the internet...yours is science-based and your presentation of it was on point. Thank you!

    52. Mark

      Great video thanks for the effort

    53. Dilpreet Sekhon

      Loved loved loved this. Thank you.

    54. Cowabbs

      Thank you for the video! I LOVE your academic content, I find it very inspiring. I would really like to see more scientific content in your instagram :)

    55. Joan H Bromley

      Aspartame and Sucralose are terrible migraine triggers for me and my sister. I wonder how many other people experience migraines triggered by artificial sweeteners? Saccharin is the only artificial sweetener I can use and the only one that doesn't have a funky chemical taste.

    56. Aye Right


    57. Thomas Wheeler

      If you want to jump around

    58. anand wayne

      no calories no problem.......

    59. Kaito

      1000 thumbs up, nice work!

    60. Tanjams

      It's really nice to see someone who's so influential, covering this topic in a rational, science based approach.

    61. Marina Strom

      Lol I’m watching this in 2020

    62. Metaris

      Very informative! Thank you.

    63. Saša Bičkošová

      HI. So I just wanted to thank. I watched this video first when it got released 2 years ago and actually saved it. Now I got an assignment from my English teacher to write a discursive essay. I chose this topic. This video is very helpful to me because it covers all the bases and the major arguments regarding this topic. So thank you once again for putting in the hard work and effort in reseaching this topic. It served me well.

    64. Ross Adams

      could anyone direct me to if formaldehyde is created from when artificial sugar Acesulfame-K is left for a few days . I have noticed that it smells very strong of some type of paint thinners like acetone of some sort. I read that in Gulf war the Coke turned to formaldehyde under the tarps in the hot sun. So I am guessing similar mightt be occurring.I find this occurs in any juice concentrate that has Acesulfame-Kin it. Like Ribeana etc

    65. Henrik Sørensen

      Jeff is a lucky guy 😁👌

    66. Eric Castillo

      I'm concerned about two small packages a day good or bad long-term?

    67. My Yy

      I love this! I love these information. It helps me know what to put in my body. I enjoy all your videos, but these are my favorites because I can get educated as I'm working out and it makes me more aware of what my next meal will be. Thank you for all your hard work!! ❤❤

    68. Nikhat Pathan

      Thank you for the knowledge... Loved it

    69. Tom Holmes

      Hi Stephanie, Found this useful, has anything changed in recent years? Also I've heard sucralose use in cooking / heating is linked to cancer.

    70. Ben Valenti

      WOW the media lied to us what an finnin surprise

    71. MemeMaster64 Official

      Asparatame or Aspartame???? Lmao

    72. Tamar Harrington

      What about sugar alcohols like erythritol and xylitol? Have those been studied much? (Of course, theyr're not entirely non-caloric, but pretty close.)

    73. gideondavid30

      It affects the gut biome.

    74. MrOrigamitsunami

      look at all the simps talk

    75. valanaba13


    76. James Vacca

      Fantastic work! Thanks for sorting through all the data and presenting it in such an easy to understand form.

    77. violinsheets

      Artificial sweeteners hijack your brain and disregulate your dopamine receptors so that over the years you start eating exclusively for pleasure rather than for nutrition. I fell victim to this. 5 years ago, I started by drinking 1 can of Diet Coke a day. A few years later, I was obese, drinking entire bottles of it like it was nothing on a daily basis, not because I wanted it, but because I was treating it as a stimulant and loved the high that I got from it. I stopped drinking it, a year later I lost hella weight. I don’t understand how a dose dependent response is weak evidence. How much stronger evidence can you possibly find in a nutrition study

    78. Peter Oldroyd


      1. on Enabled

        Yes. So?

    79. Peter Oldroyd


    80. Cristina Lee

      Simply amazing, well researched! Everything I needed to know.

    81. symph tah

      Currently prepping for a competition and have prepped multiple times indulging in artificial sweeteners when I have a craving (for me means that women thing that happens once a month lol) and I never gained weight, I was always in a caloric deficit obviously when prepping and I neither retained water nor gained weight with artificial. Everything in moderation and a balanced diet is the key to success people! Great job steph! I really liked this video... don’t believe everything you hear on the news people! Do your scientific research I.e. peer based review and scientific journal sources 🔑

    82. Skeptical Cat

      I know this is an older vid of yours but I really appreciate it. This eases my anxiety about having a reasonable amount of artificial sweeteners. I really enjoy having a can of fruity sparkling water a sugar-free jello cup everyday.

    83. Facts Over Emotions

      Aspartame makes me feel like shit. Sucralose hasn't harmed me yet though.

    84. Christopher Kellum

      I watch this as I sip on my Pepsi zero 😎

    85. Quinten Saija

      Great review

    86. David Wagner

      Awesome content!

    87. G Dubrovskaya

      I'm kinda curious as to what you think about the effects on gut microbiome - is it significant enough for us to worry about? Thanks :) this video was very helpful

    88. joseph aquino

      Finally! Thank you very much for this awesome review. I can take Whey again

    89. Carlos Giron

      Excellent research, greatings from México

    90. David Sewell

      So until a scientific study comes out to say otherwise. Then go to town. Sweet!

    91. Sergey Dzyubanyuk

      Go ahead eat and drink? Here is the link for people who would like to read them self :

    92. Wallace Bonner

      My concern isn't necessarily with just artificial sweeteners but with processed foods in general. I remember reading or hearing somewhere that the body doesn't know how to digest man-made chemicals found in a lot of processed foods, so it stores those chemicals in your fat cells, thus increasing the size of your fat cells, leading to weight gain. Do you have any knowledge on this?

    93. randomjabify

      Aspartame manufacturer Searle manufactured their testing data when filing with the FDA. It was so bad the US Attorney started an investigation of Searle. Six months into the investigation the same US attorney was hired by Searle. Searle then hired a congressman and hired former secretary of defense Donald Rumsfeld to be its CEO. The statute of limitations expired on the investigation and, despite increasing support by independent studies that aspartame was a poison, the Reagan administration approved use of aspartame in dry foods. Methanol is poisonous. The foods that contain methanol also contain ethanol which counteracts the harmful properties. Phenylalanine accumulates in the brain and leads to depressed levels of seratonin. Etc etc etc. Basically every “scientific” organization that has written in support of the safety of artificial sweeteners is funded by Monsanto. Videos like yours With your cheery smile are dangerous.

      1. Kim Scheibel

        "Etc etc etc."? This really illustrates how you've already made up your mind about what the evidence will show: You're assuming that even unmade arguments and unpresented evidence will support your pre-judged conclusion. Confirmation bias is a very powerful cognitive trap for all of us and it is typically what separates science from pseudo-science.

    94. Timzart7

      Good discussion, but your background music, while not overly loud, is completely unnecessary.

    95. Gary K.

      Very informative and easy to understand, Awesome job keep up the good work.

    96. Elias Spegel

      The people who disliked this video are moms and grandmoms

    97. Robbie Gordon

      How many a day or week is considered moderation?

    98. Matthew

      Curious, did you go straight to the manufacturers of these products to get your info?

    99. Frederic Osei

      First time here, subscribed after this video

    100. Darkchylde50

      That was a lot of info! Hats off for all that digging around & presentation! I really enjoyed it, thank you! 😊